Core Characteristics
Dual-Functional Structure for Versatility
Its molecular chain contains both hydrophilic pyrrolidone groups and hydrophobic vinyl acetate groups. This unique structure endows it with excellent water solubility while maintaining moderate water resistance, making it more adaptable than single-group polymers in diverse formulations and environments.
Low Hygroscopicity for Enhanced Stability
Compared to polyvinylpyrrolidone (PVP), Copovidone VA64 exhibits significantly lower moisture absorption. For example, when stored at 75% relative humidity for 72 hours, PVP may absorb 15-20% moisture by weight, while Copovidone VA64 only absorbs 3-5%. This property is critical for moisture-sensitive products, effectively preventing caking, degradation, and extending shelf life.
Superior Film-Forming Ability
It forms transparent, flexible, and strong water-soluble films with a tensile strength of 15-20 MPa and an elongation at break of 100-150%. This makes it exceptional in coating and film-forming applications, providing a protective barrier to enhance product appearance and performance.
Application Fields
Pharmaceutical Industry
Binder for Solid Dosages
Widely used in wet granulation, dry granulation, and direct compression processes for tablets. Adding 2-5% Copovidone VA64 in direct compression can significantly improve granule compressibility: tablet hardness increases from 50-60 N to 80-100 N, and friability decreases to below 1%, effectively enhancing tablet quality.Film-Coating Agent
Used in tablet film coating, it delivers high gloss and strong adhesion, effectively masking unpleasant tastes and preventing moisture. Compared to commonly used coating materials like hydroxypropyl methylcellulose (HPMC), Copovidone VA64 films exhibit 20-30% better moisture resistance at the same thickness and stronger adhesion to tablet cores, reducing the risk of film peeling.Carrier for Solid Dispersions
Improves the dissolution rate of poorly soluble drugs. For example, when used as a carrier for a poorly soluble drug, the drug’s dissolution rate within 15 minutes increases from 20-30% (raw drug) to 70-80%, significantly enhancing bioavailability.
Pore-Forming Agent in Sustained/Controlled Release Formulations
Ensures reproducible release profiles in sustained/controlled release preparations. By adjusting its dosage and particle size, drug release rates can be precisely controlled to meet strict requirements such as USP/EP consistency evaluations.
Cosmetics Industry
Film-Forming and Styling Agent
In hair sprays, waxes, and gels, its excellent film-forming and adhesive properties provide long-lasting styling effects while maintaining natural shine and softness of hair. Added at 3-8%, it forms flexible, water-resistant films that resist daily environmental factors affecting hairstyles.Moisturizing and Conditioning Agent
With good moisturizing properties and skin affinity, it acts as a moisturizing film and conditioner in skincare products. It forms a moisture-retention film on the skin, reducing water loss. Tests show that skincare products containing 1-3% Copovidone VA64 maintain skin moisture levels at a high range for 4 hours, increasing by 15-20% compared to pre-application, helping delay skin aging.
Other Industrial Fields
It is also used in industrial products requiring thickening, bonding, or film-forming. For instance, in some water-based coatings, it serves as a thickener and film-forming aid, improving coating stability and film quality, resulting in more uniform and durable coatings.
Product Advantages
Superior Performance: Combines the adhesiveness of PVP and the flexibility of VA, offering comprehensive and balanced properties to meet complex formulation and process requirements.
Reliable Quality: Strict quality control from raw material procurement to production, adhering to international standards. Advanced automated control systems ensure precise regulation of key parameters (reaction temperature, time, raw material ratio), guaranteeing consistent and uniform quality across batches.
Mature Technology: With years of production experience and continuous process optimization, it achieves high efficiency and cost competitiveness, effectively reducing customers’ procurement costs.
Comprehensive Technical Support: Equipped with a professional technical team, providing full-range application support—from product selection and formulation design to production process adjustment—offering one-stop solutions to help customers launch products quickly.
