Core Characteristics

Highly Efficient Disintegration Performance
As a super disintegrant, Crospovidone XL possesses rapid capillary activity and strong hydration capacity. When tablets come into contact with water or body fluids, it quickly absorbs moisture and swells, with a swelling coefficient of 2.25-2.30, promoting rapid tablet disintegration. Compared to traditional disintegrants, under the same dosage, tablets using Crospovidone XL show a 30%-50% faster disintegration rate, significantly improving drug release efficiency.
Unique Microstructure
Its powder particles have a porous microstructure with a large specific surface area. This structural feature not only allows it to absorb water quickly but also enables full contact with active pharmaceutical ingredients, enhancing the dissolution-promoting effect on poorly soluble drugs. For example, after adding Crospovidone XL to some poorly soluble drug formulations, the drug dissolution rate within 15 minutes can be increased from the original 20%-30% to 50%-60%.
No Gel Formation
During the disintegration process, Crospovidone XL does not form a gel like some disintegrants, thus avoiding the problem of delayed disintegration or drug dissolution caused by gel blocking water from entering the tablet interior. This ensures a smooth tablet disintegration and drug release process.
Good Stability
It has stable chemical properties and is not prone to chemical reactions with most inorganic or organic acid drugs. Under conventional storage conditions, it can maintain its physical and chemical properties for a long time, providing strong support for the long-term storage and quality stability of pharmaceuticals.

Application Fields

Pharmaceutical Industry

• Tablet Disintegrant
  Widely used in direct compression, dry or wet granulation compression processes, with an addition concentration of usually 2%-5%. It is particularly widely used in high-end tablet varieties, significantly improving tablet quality. For example, in the preparation of azithromycin dispersible tablets, the addition of Crospovidone XL greatly improves the uniformity, dissolution rate, appearance, and hardness of the tablets.

• Dissolution Promoter
  Using co-evaporation technology, poorly soluble drugs are first adsorbed on Crospovidone XL, and then the solvent is evaporated, which can effectively increase drug solubility and improve dissolution rate. Taking a poorly soluble antidepressant drug as an example, after using this technology, the drug dissolution rate increased by approximately 40%.

• Dry Binder, Filler, and Excipient
  It can be used in tablets, capsules, and granules. Its small particle size can reduce streaks on the tablet surface during compression, improving tablet uniformity, with a common dosage of 20-80mg per tablet.

Food Industry
It is often used as a filter aid in the production of wine and vinegar, effectively removing enzyme and protein impurities, and improving the clarity and quality of products.

Botanical Medicine Field
Due to its ability to form stable complexes with polyphenols, Crospovidone XL can be used to refine water-soluble or alcohol-containing herbal extracts and tinctures, enhancing the stability of botanical medicine products.

Product Advantages

• Excellent Performance: Its disintegration effect is significantly better than ordinary disintegrants such as starch and sodium carboxymethyl starch, greatly shortening tablet disintegration time, improving drug dissolution rate, and effectively enhancing drug efficacy.

• Reliable Quality: The production process strictly follows international and domestic pharmacopoeial standards. From raw material selection to finished product delivery, it undergoes multiple quality inspection procedures to ensure stable and uniform quality of each batch.

• Wide Application: Suitable for various pharmaceutical dosage forms and production processes, and also performs well in the food and botanical medicine fields, providing diversified application options for customers in different industries.

• High Safety: Generally regarded as non-toxic and non-irritating, with no adverse reactions found in short-term animal tests. It meets relevant safety regulations and can be safely used in various products.